Long Term Survival and Limb Salvage in Patients With Non-Revascularisable Chronic Limb Threatening Ischaemia

ObjectiveThe aim of this study was to provide long term survival and limb salvage rates for patients with non-revascularisable (NR) chronic threatening ischaemia (CLTI).MethodsThis a retrospective review prospectively collected data, derived from randomised controlled trial (JUVENTAS) investigating the use regenerative cell therapy. Survival index in CLTI without viable options revascularisation at inclusion were analysed retrospectively. The primary outcome amputation free survival, composite salvage, five years after original trial.ResultsIn 150 NR-CLTI, 43% inclusion. This driven by an equal rate all cause mortality (35%) (33%). Amputation occurred predominantly first year. Furthermore, 33% those subsequently died within investigated period, median interval 291 days.ConclusionFive initial need revascularisation, about half who deemed survived limb. Although prospects these high risk are still poor, under optimal medical care, seems comparable that revascularisable patients, while major one year, especially among NR-CLTI ischaemic tissue loss, is very high. (CLTI). trial. In days. Five